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1.Product Specification:
DIGOXIN Basic information
Product Name:DIGOXIN
Synonyms:(3beta,5beta,12beta)-3-((o-2,6-dideoxy-beta-d-ribo-hexapyranosyl-(1-4)-2,6-dide;-12,14-dihydroxycard-20(22)-enolide;14-dihydroxy-,(3beta,5beta,12beta)-xopyranosyl)oxy]-1;14-dihydroxy-,(3beta,5beta,12beta)-y)-1;-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.)-2,6-dideoxy-beta-d-ribo-he;acygoxin;card-20(22)-enolide,3-((o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1-4)-o-2,6-di;card-20(22)-enolide,3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.)-o
CAS:20830-75-5
MF:C41H64O14
MW:780.94
EINECS:244-068-1
Product Categories:Organics;Biochemistry;Glycosides;Steroidglycosides;Steroids;Sugars;Trisaccharides;Intermediates & Fine Chemicals;Pharmaceuticals;ATPase;Carbohydrates & Derivatives;Steroid
Mol File:20830-75-5.mol
DIGOXIN Chemical Properties
mp 248 °C
refractive index 12 ° (C=10, Pyridine)
storage temp. Refrigerator
Merck 14,3167
EPA Substance Registry SystemCard-20(22)-enolide, 3-[(O-2,6-dideoxy-.beta.-D- ribo-hexopyranosyl-(1.fwdarw. 4)-O-2,6-dideoxy-.beta.-D- ribo-hexopyranosyl-(1.fwdarw. 4)-2,6-dideoxy-.beta.-D-ribo- hexopyranosyl)oxy]-12,14- dihydroxy-, (3.beta.,5.beta.,12.beta.)- (20830-75-5)
Hazard Codes T,T+
Risk Statements 25-26/27/28
Safety Statements 22-36/37/39-45
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS IH6125000
F 3-10
HazardClass 6.1
PackingGroup II
Hazardous Substances Data20830-75-5(Hazardous Substances Data)
DIGOXIN Usage And Synthesis
Chemical PropertiesWhite Crystalline Powder
UsageCardiotonic
General DescriptionClear to white crystals or white crystalline powder. Odorless. Used as a cardiotonic drug.
Health HazardMaterial is a digitalis glycoside. Ingestion can cause death. Material is considered super toxic; probable human oral lethal dose is less than 5 mg/kg, a taste (less than 7 drops) for a 70 kg (150 lb.) person. Persons at risk include those taking drugs for thyroid and renal diseases. Quinidine and diuretics taken concurrently with DIGOXIN can be hazardous. It should be used with extreme care during pregnancy and in nursing mothers.
Fire HazardAvoid light.
2.Function:
1 for the treatment of congestive heart failure, congestive heart failure caused by hypertension, valvular heart disease, congenital heart disease. Heart Failure due to congestive heart failure secondary to severe anemia, hypothyroidism and vitamin Bl deficiency treatment is poor; pulmonary heart disease, myocardial severe ischemia or the activities myocarditis and myocardial outside, mechanical factors also poor.
Used to control rapid atrial fibrillation, atrial flutter, ventricular rate.
The goods for cardiac glycosides in effect, can effectively enhance myocardial contractility, heart rate, suppress cardiac conduction. Excretion less accumulation. For congestive heart failure, supraventricular tachycardia, atrial fibrillation and flutter.