Product Description
Main Contents: Camptothecin
Plant Resource: Camptotheca acuminata
Main Specification: 98%, 99% HPLC
Appearance: Light Yellow Needle-like crystal
Plant Part Used: Fruit
Extract Solution: Ethanol
Molecular Weight: C20H16N2O4
Molecular Mass: 348.35
Melting point: 260° C
Solubility: Soluble in Ethanol
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Introduction:
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today
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Function:
1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
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Storage: Store in cool & dry place, Keep away from strong light and heat.
Shelf Life: 2 years if sealed and store away from direct sun light.
WaterTreatment-Extracting-Concentrating - Drying- Mixing - Screening -Sealing-Packaging
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About us:
We are a leading manufacturer of herbal extracts and finished supplement capsules ( Vegetarian from HPMC) in China, we have produced many capsules supplements for many companies in USA and EU since 2005. We ship various kinds of extracts capsules to our clients in USA, Denmark, Greece, UK, Norway, France, Australia, Hungary...
Regarding our final supplements, your can order:
ANY SIZE BOTTLE COUNT AVAILABLE, 60 capsules, 100 capsules, 120 capsules or whichever you prefer
ANY SIZE ORDER AVAILABLE, from 100 bottles to 50, 000 bottles
BULK CAPSULES AVAILABLE
IMMEDIATE DELIVERY! (for small batch, big quantity order need 2~4 weeks, depends on your quantity)
Best quality, Competitive price, Excellent service
Wuxi Gorunjie Natural-Pharma Co., Ltd.
Add: #99, Furong MID-3rd Road, Wuxi, China.
Tel: 86-510-8262-0959 Mob: 86-150-5210-9975
Web: WWW. Grjbio. COM
Thank you for your interest for our products!
To get more information, please feel free to contact with us! Thanks!
We are ready to serve for you with super zealousness and full efforts!
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